Cardiovascular disease in patients with allergy drug selection

Autumn is the asthma and allergic rhinitis high-fat, anti-allergy, many people have become one of the essential drugs. However, not all of them for taking such drugs, particularly cardiovascular disease in patients taking more time to be cautious. Also known as anti-allergy antihistamine, according to the time-to-market has divided into three generations, we are well-known chlorpheniramine and diphenhydramine belong to the first generation; second-generation drugs are commonly used cetirizine (Sin Temin ) And loratadine (Rui Tan Kai), terfenadine (Mitel), and so on; third-generation antihistamines, including L-Cetirizine, Fexofenadine Ding, desloratadine and B F Lee hydrochloride, and so on. In addition, anti-allergy materials include calcium, such as calcium gluconate, and immunosuppressants, such as dexamethasone, cyclophosphamide, azathioprine. The first generation of anti-allergy to the heart of less side effects, but it can also cause heart beat too fast or slow, nervous, dizziness, drop in blood pressure, and so on, so that the heart failure. The second-generation anti-allergy, such as astemizole, terfenadine heart of the greater side effects, may cause arrhythmia, can lead to serious cardiac arrest and sudden death, known as the allergy drug Astemizole, It is because of too much impact on the heart had been eliminated. And the first and second drug compared to the third generation of anti-allergy fewer side effects, better efficacy, especially in the heart of the side effects are significantly lower. In addition, calcium gluconate on heart disease in patients with the same does not apply if the rapid injection or excessive doses, it will cause cardiac rhythm disorders, caused serious ventricular fibrillation or cardiac arrest. Therefore there is heart disease, the best selection of third-generation antihistamines. In addition, even when taking note of the following: Do not with erythromycin, azithromycin, roxithromycin, with the use of drugs such as ketoconazole, or antihistamines can cause the blood concentration was significantly higher , Caused a dangerous ventricular arrhythmia and even sudden death. Hypocalcemia, hypokalemia, and patients with low blood magnesium is best not to use, as electrolyte disorder can affect the heart, causing cardiac arrhythmia. To avoid the same anti-arrhythmic drugs, calcium antagonists, sedative-hypnotics combined, so as not to increase the risk of arrhythmia. Drugs should be the recommended dose range.