Cirrhosis portal hypertension caused by what harm

Portal hypertension is increased pressure on the portal. Portal is the liver of a larger population of the vein, the superior mesenteric vein and the vein of spleen from merging, in the liver is divided into two doors into the human liver. 75% of the liver's blood from the portal, 25 per cent from the hepatic artery. Mainly responsible for the collection of the esophagus, stomach, intestine, pancreas, gallbladder and spleen of intravenous blood. Under normal circumstances, the portal pressure to 0.7-1.5 kPa, more than 2.0 kPa that have clinical significance. Percutaneous puncture spleen measured pressure within the spleen may be permanent representative of portal pressure. When liver cirrhosis or liver, portal blocked blood flow, can make portal hypertension, and, congenital dysplasia, or abnormal tumor suppression also increased pressure on the portal. These diseases can cause substantial damage Gan Xiaoye, such as liver cell necrosis, the capillary network damage, followed by liver nodules and connective tissue, fibrous tissue proliferation. A long time, so that the liver vascular deformation, obstruction, interrupted blood flow deposition. When venous outflow obstruction serious liver, liver cells hypoxia ischemia, increased liver cell necrosis. Intrahepatic resistance to increase. In this case, portacaval only to increase their systolic pressure, by thickening the blood vessels to carry out compensatory. Over time the formation of portal hypertension. Long-term portal hypertension caused a series of complications, such as in congestive splenomegaly, gastrointestinal, and the peritoneum of chronic heart, such as the establishment of collateral circulation, said portal hypertension. Portal hypertension will lead to esophageal varices, abdominal and rectal varicose veins. When esophageal varices and to a certain extent, in the role of external factors, to break down, cause upper gastrointestinal bleeding. Performance for the large number of hematemesis or tar-like stools, rectal bleeding caused when massive blood in the stool. Portal hypertension will appear enlarged spleen, abdominal distention, Nacha, abdominal multiple organ congestion, hypersplenism. Splenomegaly and hypersplenism make red blood cells, WBC and platelet destruction increased, and cause anemia, as lower blood, the lower immune function, decreased body resistance. Portal hypertension is a ascites, peritonitis, sepsis direct factor. The emergence of ascites, often easy to create an effective cycle of blood shortage, blood pressure dropped, electrolyte disturbance, involving the heart, brain, kidney and other organ functions. These serious complications, at any time endangering the lives of patients.