Sunday, February 17, 2008

Elderly renal transplantation particularity and the main reason for failure?

The elderly than young people renal transplantation due to the low success rate of the characteristics of its own decision, the elderly kidney transplantation have their special features, mainly in the following aspects:
1, the elderly because of the recession in the immune system, so that it weakened the ability to fight infections, coupled with the use of immunosuppressive drugs, the infection after renal transplantation significantly increased the incidence and manifestations of unknown
Significantly, but has critical condition, poor treatment response.
2, the elderly, such as cardio-cerebral vascular disease complications, blood pressure fluctuations, the degree of anemia tolerance of difference, once after renal transplantation early recovery of renal function is not satisfactory, vulnerable to the above-mentioned causes heart
Cerebral vascular accident and emergency life.
3, the elderly suffering from uremia after the obvious damage to the system, the functions of the various organs less reserves of the immunosuppressant drugs such as tolerance of difference, prone to drug toxicity, and because
The types of drug use, prone to drug interaction between affected Cyclosporine A in plasma, leading to frequent adjustments of the type and dose of drug, the difficulties brought about treatment.
4, the elderly after renal transplantation due to the decreased immune function, renal allograft rejection in the relatively less than young people, suffering from cancer and other opportunities for increased significantly, and the cerebral blood for a variety of heart
Of disease and infection complications, many of the elderly after renal transplantation death transplantation with normal renal function.
Elderly kidney transplant failure was mainly due to patients with other causes of death, which is the main reason for acute myocardial infarction and other heart disease, followed by infection, the third was a vicious swelling
Aneurysm, is once again the gastrointestinal perforation, bleeding and diabetes.

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