Multi-infarct dementia completely cured yet more difficult, But through therapy can improve symptoms more. The treatment principle is:
(1) activation of brain metabolism, indirectly inhibit the development of dementia. Availability of cerebral circulation and promote brain metabolism agent. Cerebral circulation promotion is a direct expansion of cerebral vascular drugs, and brain metabolism agent that through the promotion of glucose absorption, metabolism, the brain vascular secondary expansion, improved nutrition metabolism of drugs. The two are closely related and influence.
① promoting metabolism of the brain: the brain benefits triazine, flunarizine, which were the phenol benzyl amine formulations, and other alkali and ergot. Simple vasodilative banned drugs, only because it will lead to expansion of vascular blood pressure dropped so that the dementia increased.
② brain cells agent: new brain rehabilitation, meclofenoxate, Hite Kum, coenzyme Q10 , CDP - choline, live in the brain, are gratifying, Prabhakaran tablets, etc..
(2) neural transmission organizations disorder treatment
① high-calcium pantothenate can promote glucose uptake and metabolism of the brain, increased brain tissue and 5 - serotonin concentration and cerebral blood flow, to improve neurological symptoms significantly. Dosage 250 mg three times a day after meals served.
② Amantadine can promote the release of dopamine, inhibit its uptake. The daily 100 mg, two weeks after dementia patients can increase appetite, flexible stand, dress, walk, raising activities and emotional interest in capacity. Side effects are headache, lethargy, gastrointestinal metabolic disorder. Large doses can cause convulsions.
③ cholinergic drugs mainly referring to cholinesterase inhibitor (drug lentils base, tetrahydrocannabinol amino pyridine) and acetylcholine precursor drugs (lecithin, choline chloride, dimethylamine ethanol), can increase acetylcholine system functions, and improve the clinical symptoms.
④ neuropeptide can improve understanding and memory of older persons, reduce depression and inability. Dosage: ACTH25 μ plus 5% glucose 250 ~ 500 ml infusion, the slower speed, not long used.
⑤ medicine soup can Huanglianjiedu whole brain average , and the hippocampus memory around the more obvious increase, increase blood flow around ischemic foci, narrow infarct lesions. Currently, Japan has for the treatment of multi-infarct dementia.
(3) symptomatic treatment clinical application of regular anti - psychosis, antidepressants, anti-anxiety drugs. Most antipsychotic drugs may be particularly useful, can resume normal sleep - wake cycle, control impetuosity and excessive behavior, improve self-care ability. Common methylthio of triazine Fluphenazine, which were the fluoride such as n-butanol. The depression also can be used stimulants, such as Ritalin, meclofenoxate. Given the anxiety, such as stability.
(4) In addition to support therapy on the patients should be given adequate nutrition and life care, and patients should be more contacts, more conversation, and allowed to watch television and more books, newspapers magazines, take part in social activities and physical exercise, and avoid patients social isolation, in order to reduce loneliness.
Thursday, February 28, 2008
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