Saturday, March 29, 2008

Autosomal dominant hereditary disease ichthyosis

Autosomal dominant hereditary unusual ichthyosis, This is a common type of light ichthyosis, substituting one or both parents were home sick more often with catalyst, but no gender differences. Often, a child morbidity, and increased with age, to the most obvious symptoms of adolescence, that is, after the cessation of development. Lesions performance of different degrees of seriousness, the only light to the winter dry skin, no obvious,after powder loading debris, known as dry skin disease. I see hair follicle or in the size of a tip of the hair follicle and brown, without consciously disease, known as hair follicles of ichthyosis (ichthyos; sfoll; cularis). In addition to common skin drying, the idea that or deep brown, central fixation, the free edge. Also was gray and white, with mica-like sheen, gloss of ichthyosis called. More significantly abnormal proliferation of keratinocytes; lcm above can be thick, rough surface, or a spine-like uplift papillary surface dark gray, like bark, herein referred to as superb ichthyosis.
Friends of the disease in the symmetric stretch limbs and trunk side, particularly Zhouxi side for a stretch. Severe cases can be spread to the body, with palmoplantar hyperkeratosis, and that the saddle cleft (toe) A change. Hill like face, scalp, elbow Waterloo, armpit, gills Waterloo, genital, and Tungou often not be violated, or only mildly . Usually without conscious of the winter due to decreased secretion of sweat glands and sebaceous gland, skin drying, and consciously itching discomfort, if the lesion is flu pain. Often patients with atopic constitution, such as fever and asthma subtilis.
Pathology: cuticle significant thickening, particle layer thinning or disappeared. The stratum corneum and stratum corneum cells thickening the desmosome slow degradation, cuticle off the normal cells failed. Spike thin layer cell, basal layer pigment increase. As Hyperkeratosis enter into hair follicle formation of hair follicles Kok suppository. Adenovirus can sweat gland cortical atrophy. No significant changes in the dermis, or in a small number of perivascular lymphocytic infiltration.

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