Children rheumatoid etiology and pathology of

Children of Rheumatology is a relatively common systemic connective tissue disease, the main clinical manifestations of a long-term irregular fever, and large, medium and small joint swelling (especially Zhizhi small joints), so time can be formed joint deformities, accompanied Han, spleen and lymph nodes body, and since cell anemia, such as increased. Children aged less, its clinical manifestations are somewhat more systemic symptoms, older children or adult patients more limited joint symptoms. Therefore, in the category often called Pediatric Rheumatology, than in the past with the "rheumatoid arthritis, a more comprehensive title. Children and adults with chronic rheumatic diseases like rheumatoid arthritis and there are still more differences. If I have more systemic performance (flip-fever, rash, liver and spleen enlarged lymph nodes, and significantly increased the total number of leukocytes), and joint disease lighter, sometimes with iridocyclitis, pericarditis, cervical spine involvement; On the other hand relatively rare in children subcutaneous nodules, rheumatoid factor positive rate lower. Cause has not yet fully appreciate, and is generally believed that the allergy and autoimmune. May be due to virus, or other pathogen mycoplasma infection continued to own lgG occurred degeneration become antigen to stimulate the body create a so-called rheumatoid factor antibodies, which are IgM antibody category. One of the elements of serum rheumatoid factor and five autoantigen IgG with the formation of a complex, this complex antigen-antibody reaction with all the characteristics of precipitation in the body tissue, in particular joint, synovial, after the activation of complement attract neutrophils and the release of the lysosomal enzyme (protein enzyme decomposition), the cause of vascular basement membrane and the nearby organizations, including synovial damage. Pathological changes in the pathogenesis of the disease mainly occurred in the joints, but it can also involve other parts of the connective tissue. First of all intra-articular synovial invasion, early congestion, edema and lymphocyte infiltration, and then was villous synovial thickening, and the final formation of granulation tissue. Soft tissue around the joints also swelling. Continue to develop inflammation, granulation tissue from the edge of the articular cartilage of the synovial membrane to the cartilage gradually began to extend the coverage of the final will be cartilage, the cartilage from Gunang interdictions of nutritional intake, therefore, cartilage surface ulcers. At the same time, subchondral bone marrow also lymphocyte infiltration and formation of granulation tissue, cartilage stripping. Finally cartilage surface of granulation tissue fibrosis and even ossification, and the upper and lower arthrodesis ankylosis. Was near the articular bone decalcification and osteoporosis, muscle atrophy, joint capsule and ligaments may also be granulation tissue invasion caused dislocation. They can also be seen subcutaneous nodules, myocarditis, pericarditis, iridocyclitis go far.