Tuesday, March 11, 2008
Pregnancy with hepatitis
Overview of Hepatitis A, B and non-A, non-B (or C) type caused by the hepatitis C virus liver disease. B liver with hepatitis B virus surface antigen (HBsAg), hepatitis virus from food, blood transfusion, Injection and other close contacts such as infection. Recently found in the blood, urine, semen were HBsAg, which can be transmitted through sexual life. Fatigue and malnutrition is the major reason for priming. 1, the pregnancy on the impact of viral hepatitis with viral hepatitis during pregnancy, no special effects, However, fetal growth and development, massive caloric and vitamin, protein, liver glycogen metabolism, add to the burden, if the sugar shortage million reserve, can cause liver function obstacles, the pregnancy more easily bigots. In the third trimester of pregnancy sickness, particularly jaundice hepatitis, and the development of acute or severe hepatitis, Subacute yellow atrophy of the liver than the non-pregnant, the fatality rate has been high. In the delivery process, hemorrhage, trauma surgery, anesthesia and physical exertion, we may add to the symptoms of hepatitis. If with preeclampsia, in necrosis of the liver cells on the basis of aggravating the injury to the liver, can cause large area necrosis. General types of hepatitis, duration and liver function returned to normal with the same non-pregnant, but severe cases, the recovery slower. Or the development of chronic persistent hepatitis, and there is no distinction between non-pregnancy. 2, viral hepatitis on the impact of pregnancy early pregnancy sickness, pregnancy can increase response. In the third trimester of pregnancy sickness, pregnancy-induced hypertension was higher than that of non-pregnant. Meanwhile pregnancy with preeclampsia and hepatitis serious consequences. Because liver dysfunction, coagulation affected, the incidence of postpartum hemorrhage rate was also increased. In early pregnancy illness, deformity rate of newborns has not increased, but with advanced disease, premature births, stillbirths, stillbirths and neonatal mortality rate increased significantly. Has confirmed asymptomatic hepatitis B virus carriers, newborns born to HBsAg positive about 5 ~ 7%. speculate may be transmitted through the placenta, as in the second half of pregnancy sickness, fetuses and newborns of HBsAg positive rate of about 20 ~ 30%. Some newborns at birth antigen negative, after the sub-positive morbidity, may be due to inhalation of fetal birth canal blood or fetal damage caused by the introduction of the skin. Therefore pregnancy sick time, the effects of fetal exposure was different. Diagnosis of acute hepatitis in the diagnosis of hepatitis is characterized by the early symptoms of pregnancy with a similar reaction, vulnerable patients and the doctors ignored until serious symptoms, we find very often affect the prognosis. Besides pregnancy diagnosis of viral hepatitis, can not be one-sided emphasis on the importance of elevated transaminase. But there Pregnancy gastrointestinal symptoms such as nausea, vomiting, loss of appetite, to think of the possibility of hepatitis. should be asked in detail about the history, as close contact, blood transfusion and injection history, and do all the determination of liver function, timely detection and treatment. Hepatitis with jaundice hours without jaundice two. The latter less than 20%, or about 80%, have more fatigue, anorexia, liver pain, course development relatively slow. Icterohepatitis one week after the onset of jaundice occurs around, sclera and yellowish discoloration of skin, blood bilirubin increase, TB with cholestasis during pregnancy liver disease identification. The latter complained of light or no complaint, except jaundice often outside skin itching, normal aminotransferase, Laboratory investigations blood bilirubin rarely exceed 5 mg%. Jaundice hepatitis symptoms can sometimes suddenly intensified, after the onset of 7 ~ 10 days, jaundice sexual deepened and sustained drama vomiting, fever, headache, particularly serious, rapid onset, jaundice and hypoglycemia may weight, expressed serious liver necrosis, patients irritability, delirium and go into a coma. Such severe jaundice during pregnancy, also known as hepatitis pregnancy acute yellow atrophy of the liver, a high mortality rate. Acute yellow atrophy of the liver with fatty liver of pregnancy differentiate fatty liver of pregnancy outbreaks of disease onset anxious, aminotransferase was not significantly higher, blood and urine bilirubin high bilirubin negative. Jaundice, coma and dehydration, eventually there hepatorenal syndrome. Taken with the severity of the same basic treatment, the prognosis is poor. Correct identification of liver biopsy, viral yellow atrophy of the liver pathological changes is the breadth of liver cell necrosis, Fatty liver is the same was true of diffuse fatty degeneration. Treatment of pregnant women with hepatitis, if not actively treated for heavy easily. Therefore any confirmed or suspected hepatitis, to be aggressive treatment, including adequate rest and nutrition. Early pregnancy is for abortion, views are not unanimous. The mid - and late pregnancy patients, termination of pregnancy is not appropriate. Therefore, any drugs or abortion, can increase the burden on the liver. And attention to the prevention of severe pregnancy-induced hypertension. Late sick to the pregnant women and fetal effects of larger, it should strengthen the treatment and observation. Attention to the prevention and dysfunction of coagulation (DIC), the delivery of fresh blood properly. Vitamin K1 used to enhance coagulation function, prevention lag production, shorten the second stage of labor, to reduce physical exertion. Prevent injury and post-partum hemorrhage. Severe hepatitis attention to any signs of DIC. Blood pressure and urine to prevent hepatorenal syndrome. Puerperal infection prevention, the application of liver damage without antibiotics. Neonatal cord blood to stay for liver function and antigen test, negative hepatitis may still happen. and every one must be isolated neonatal care, and pay close attention to any symptoms of hepatitis. Not breastfeeding. Milk to mothers when it is not appropriate to use estrogen to prevent liver damage.
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