Renal amyloidosis how diagnosis?

Amyloidosis refers to the chronic extracellular insoluble fiber silk protein deposition uniformity, the amorphous material characteristics of a group of diseases collectively. Clinical divided into primary and secondary amyloidosis two. No cause of the former base, The latter often secondary to chronic inflammation or infection of the disease (such as tuberculosis, osteomyelitis, bronchiectasis, lung abscess, etc.), tumors (multiple myeloma, Hodgkin's disease, etc.), the minority view of familial genetic diseases (such as familial Mediterranean fever). At present, most of immunohistochemical characteristics of classification, primary amyloidosis and multiple myeloma induced amyloid protein for the AL amyloid protein, secondary AA amyloidosis for protein. Amyloid material available in the various organs and tissues in the vessel wall in the deposition, a multi-organ disease, kidney is the most common organ involvement. This material by amyloid deposition in the kidneys caused by kidney disease. Called renal amyloidosis.
The diagnosis of this disease depends on the renal biopsy or skin lesion biopsy. Patients with renal tissue changes: Endoscopic glomerular mesangial area or within a wide range of transparent transformation with capillary basement membrane thickening, specific material Mission massive amyloid deposition. Electron microscope that amyloid fiber deposition. Immunofluorescence examination showed IgA, Cl, C2, C4 fibrin wall of the capillary membrane and small arteries and interstitial tubular wall deposition. Congo red test positive test helps identify AL potassium permanganate or AA.