Traditional treatment of lupus nephritis is the hormone drugs, but in recent years the clinical practice shows that use of the poison cell therapy, especially the use of cyclophosphamide for intermittent impact than simply using hormone therapy to better effect. Therefore, the treatment of lupus nephritis mainly cyclophosphamide plus hormone, rather than simply using hormone.
(1) hormone: general use of prednisone, the first stage before treatment, adult 1 mg / kg daily morning Dayton served until eight weeks after the issuance, by 5 mg per week, to small dose (1 mg of yesterday morning / kg) to Dayton next day morning service, according to the specific situation persists for a period of time, continue to better effect reductions until maintain volume (Overnight morning 0.4 mg / kg). Some people think that, lupus nephritis patients should be taking hormone life, the general amount of prednisone every other day morning serving 10 to 20 mg. It is worth noting that before the first dose of hormones must be adequate, inadequate dose (<30 mg / d) is often ineffective, glomerular lesions will continue to progress and become irreversible fibrosis caused by renal failure.
Fulminant or particularly serious illness, high fever up to 40 ℃, extensive rash and Purpura, proteinuria, can also be used large dose hormone therapy. If the unconditional use of methylprednisolone, dexamethasone used 150 mg / d instead, the effect good.
(2) cyclophosphamide: to curb the activities of lupus nephritis, stabilize its course, reducing hormone dosage, and specific antibody inhibited the effect particularly good, the elimination of lupus nephritis non-specific inflammation and T lymphoid cell-mediated immunity also good effect. Research shows that cyclophosphamide pulse therapy more sustainable and better use of fewer side effects. Foreign use of cyclophosphamide 0.75 ~ 1.0 g/m2 each body surface area, intravenous infusion every three months to a shock 1 At the same time, small dose oral prednisone. Improved domestic cyclophosphamide pulse therapy, please refer to the aforementioned related content.
Friday, April 4, 2008
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