Friday, April 4, 2008

Systemic Lupus Erythematosus kidney damage the pathological changes is how to type?

Lupus nephritis histological changes can be divided into activities of the indicators (A1) and chronic Index (CI). Glomerular lesions, activity indicators include: cell proliferation, cellulose necrosis, nuclear fragmentation, the cells of the crescent, transparent kind thrombosis, platinum ears like change and leukocyte infiltration, chronic indicators of glomerular sclerosis and Fibrous crescent. Tubulointerstitial lesions, activity index for mononuclear cell infiltration of indicators including chronic interstitial fibrosis and tubular atrophy. According to the 1982 WHO classification criteria, lupus nephritis by pathological changes differences divided into six types: Ⅰ type: normal glomerular A light microscope, electron microscopy and immunofluorescence no abnormal changes; B, normal light microscope, but immunofluorescence and / or electron microscopy mesangial area immune complex deposition. Type Ⅱ: mesangial lesions A, mesangial matrix widened with mild or mesangial cell proliferation B, in the middle of mesangial cell proliferation Ⅲ type: the focal segmental glomerular nephritis (with light or moderate mesangial lesions) A, including dynamic necrosis lesions B, and activities sclerosis lesions C, sclerosis lesions Ⅳ types: diffuse proliferative glomerulonephritis (mesangial - capillary proliferation / endothelial under extensive sediment) A, no nodular lesions B, including dynamic necrotizing lesions C, activities and hardening of the lesion D, sclerosis lesions Ⅴ type: membranous glomerulonephritis A, simple membranous nephropathy B, lesion with Type Ⅱ C, with Ⅲ lesions. D, with Ⅳ lesions Ⅵ type: sexual sclerosing glomerulonephritis

No comments: