IgA nephritis treatment

So far, the disease there is no satisfactory treatment. Of the disease with progressive renal dysfunction adrenocorticotropic hormone use with or without immunosuppressants are not consistent. Recent data suggest that more than one of proteinuria g / d, imposed overnight use of adrenocortical hormones useful for the improvement of proteinuria. IgA deposition with minimal change nephropathy, was likely to ease proteinuria. A combination of cyclophosphamide, dipyridamole and Huafulin reduce proteinuria and the glomerular filtration rate is not affected the use of cyclosporine A merger can also reduce proteinuria, Ran has also reduced creatinine clearance rate. Phenytoin, anti-platelet drugs, acid disodium-glycosides, such as diphenyl Hydantoin drug efficacy not sure. Despite reports of urokinase can protect the glomerular filtration rate, but far from conclusion. Recurrent tonsillitis, tonsillectomy may be useful; antibiotics for the prevention and treatment of infection in some acute nephritic syndrome and acute renal failure of performance may be helpful. Observed that a series of smaller agents with the use of fish oil to reduce proteinuria and increased glomerular filtration rate role. Severe IgA nephropathy (glomerular filtration rate monthly decline of 2 to 4 ml / min) using high-dose immunoglobulin intravenous infusion during the cease glomerular filtration rate fell to improve hematuria and proteinuria, but stop After the regular recurrence. To have hypertension and proteinuria severe cases, the use-converting enzyme inhibitors may slow down the rate of decline in glomerular filtration rate and reduce proteinuria, in severe IgA nephropathy, converting enzyme inhibitor is the first choice antihypertensive agents. Conversion of normal blood pressure inhibitors can effectively is unclear. IgA nephropathy to end-stage renal transplantation, kidney transplantation in mesangial area soon IgA deposition; if the donor kidney have subclinical IgA nephropathy, non-implanted uremia, IgA nephropathy, for the mesangial area IgA deposition were often vanish quickly. Recurrent kidney transplantation with IgA nephropathy is not inevitable for renal failure, but by the application after renal transplantation immunosuppressive therapy, including cyclosporine A and also can not prevent its development. Of cadaveric renal transplantation, 1, and three years of renal allograft survival rate up to 87% and 77%, but individual anti-HLA antigen IgA antibody IgA renal transplantation, renal allograft survival 2 years up to 100 percent, reason to believe that these anti-HLA antigen antibody on the increase in renal allograft survival has played a useful role.