Chronic eosinophilic pneumonia

Cause pathogenesis of the disease is parasitic (hookworm, roundworm, etc) and drugs (nitrofurantoin due, etc.) caused by allergic, pulmonary eosinophil infiltration of a wasting disease. Interstitial lung pathology, the bronchioles and alveolar within leukocyte infiltration, mainly mature eosinophils. Few cells and lymphocytes, alveolar cells showed eosinophilic granule containing sharp corner and crystallization of multinucleated giant cells. That this pathological features of the disease. Some of the pulmonary vessels, mainly pulmonary venous vasculitis, sometimes multinucleated giant cells and eosinophilic granuloma clinical manifestations of young and middle-aged patients with more common in women, fever, weight loss, night sweat. Cough more mucus plugs, with short breath and hemoptysis. Peripheral blood eosinophil proportion of the more than 20% -70%. Chest X-ray showed that the lack of distribution or leaves around the patchy shadows, often bilateral distribution. Glucocorticoid treatment within 48 hours after symptoms and chest can quickly disappear. In the same recurring locally, a few years later into fibrosis or honeycomb changes. Diagnosis based on the typical history course and the performance of X-ray diagnosis can be made. But with other eosinophil lung lesions with increased need for identification. Simple pulmonary eosinophil for parasites and disease caused by drug allergy, pulmonary interstitial, alveolar walls and terminal bronchiole wall eosinophil favorite, can no clinical symptoms, a small amount of mucus Qinghai sputum, Chest X-ray films showed small or large fuzzy shadows were migratory. General without treatment. Asthma pulmonary eosinophilia disease is mainly caused by aspergillosis repeatedly made as asthma characteristics of the allergic. In the alveolar and interstitial volume how eosinophil infiltration, end bronchiolectasis and full of thick mucus plugs sex may find true mycelium. Chest X-ray films was particularly prevalent in the upper wandering shadow. With glucocorticoids and antifungal treatment can control asthma, the shadow disappeared. Tropical eosinophilia syndrome such as filarial infection caused pulmonary eosinophil infiltration and tissue cells, was bronchial pneumonia can be distributed, with small bronchial necrosis and eosinophilic abscess. Asthma-like drama paroxysmal cough, sputum less difficult cough, chest tightness flu, fatigue and anorexia. Chest X said two helical increased, with miliary or vague shadow, there will be chronic interstitial fibrosis. After anti-filarial drug treatment, a few days to ease the symptoms, lung disease slowly disappear. Treatment of glucocorticoid treatment significantly, and often restore normal withdrawal easier for recurrence, the entire duration of treatment in more than a year.