Tuesday, March 25, 2008

Cushing's syndrome will not cause dyslipidemia change?

Cortisol on lipid metabolism of fat is mobilized to promote decomposition of glycerol and triglyceride fatty acid, inhibit fat synthesis, reduced fat tissue sensitivity to insulin, glucose stop entering fat cells into fat.
Because cortisol but also inhibit glucose utilization and enhance the glycogen Health different hyperglycemia, islet β-cells stimulated insulin secretion increased, therefore promote fat synthesis.
As the body fat around the sensitivity of these different hormones, which glucocorticoid excess, a concentric fat distribution, face, neck and trunk subcutaneous fat increased, but a relatively small part limbs, a "Full Moon Face" "buffalo back" unique pathological appearance.
Patients with the disease are fat mobilization and synthesis of the promotion, but the synthesis of relatively strong, the result of increased total fat, so there may be hyperlipidemia, about half of the patients in atherosclerosis.

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