Eaton-Lambert's syndrome

Overview added that category myasthenia gravis syndrome; MG-myopathy syndrome; Cancer with myasthenia syndrome. Cause pathogenesis associated with the majority in cancer, small-cell lung cancer the most common. As the motor neurons of the peripheral acetylcholine release diminishing, and neuromuscular transmission barriers. Most clinical onset after the age of 50, male styles; More associated with tumors, small cell lung cancer the most common; mainly proximal muscle weakness of the trunk and lower extremities were severe in the upper limbs; Wasting easy fatigue, had been slow. Muscle fatigue after activity, but if it continued contraction of muscle strength but will improve; see the extraocular muscles and medulla disclaimer muscle involvement; About 1 / 2 cases had abnormal limbs feeling, dry mouth, impotence; Yang Jan esterase inhibitor for the treatment ineffective. Tendon reflexes weakened without muscle atrophy. Differential diagnosis (1) severe myasthenia gravis () 40-year-old female styles; accompanied thymic tumor; Systemic muscle can be involved in activities in the most earliest muscle involvement; MG Kenneth morning light weight, activities increased after the break to reduce or disappear; tendon reflexes are usually not affected; cholinesterase inhibitor therapy. (2) Guillian-Barre syndrome pseudoaneurysm for muscular dystrophy type myasthenia limbs the main terminal, with more cranial nerve symptoms and subjective and objective paresthesia. While proximal limbs or limb-girdle muscular atrophy Department. (3) muscular dystrophy (myodystrophy) is a group of autosomal dominant or recessive genetic have related degenerative muscle disease, myasthenia gravis, atrophy or pseudo-mast to the main clinical signs. MG was slowly increasing, muscular atrophy and distribution features. (4) polymyositis (degeneration) disease progress faster, unable to focus on symptoms of muscular atrophy, Common pain and tenderness. ESR increase of corticosteroid treatment response is good. (5) hysteria and neurasthenia patients often unable to fatigue symptoms often have no day and night difference, it will be Hysterical Aphonia ball or hysteria. No muscle paralysis, vertical eyelid and eye muscle paralysis phenomenon. (6) amyotrophic lateral sclerosis (amyotrophic lateral sclerosis) motor neuron disease (cure for motor neuron disease), cranial nerve palsy (paralysis of crania nerve), Periodic Paralysis (periodic paralysis), thyroid myopathy. Acute porphyria (acute porphyria), and extreme hunger can be developed symptoms such as sexual weakness, According to the majority of clinical manifestations can be distinguished, those difficulties can be used neostigmine test. Botulism, and even the light of neomycin, streptomycin, more actinomycin blocking neuromuscular junction resulting from the tetraplegic and respiratory muscle weakness, According to an acute onset of food and special history, medication history can identify with this syndrome.