Etiology of Cervical Pathology leukoplakia

【Etiology: 　　 The cause of cervical leukoplakia not yet clear. The following factors may be relevant: 　　 (1) endocrine disorders: estrogen in the body increased, resulting abnormal cervical epithelial surface keratosis. 　　 (B) stimulate the local: Cervical as chronic inflammation, the impact of vaginal trichomoniasis. Zhongshan Medical University, in 700 cases of cervical erosion biopsy pathology clinical analysis, we found cervical leukoplakia 37 cases, or 5.2%, we can see that in cervicitis cases, the incidence has increased significantly. 　　 (C) other factors: According to the literature, even leukoplakia and cervical dysplasia, carcinoma in situ or invasive early coexist. The incidence of cervical leukoplakia that may cause cancer and cervical cancer related to the factor. 　　 【Pathological changes: 　　 General observation, we can see that the surface of white opaque cervical spot Flake region, size, shape mixed, the general lesions smaller, not more than 1 cm in diameter. A single or more, individual cases of leukoplakia could go beyond the cervix vaginal fornix. Only the surface than for the gray and white or pink mucosa around slightly shiny, marginalized some neat, clear boundaries, but some are , will be white with easily wipe the surface, the bottom point was bleeding. 　　 Seen under the following characteristics: ① the surface leukoplakia excessive keratosis or incomplete keratosis; ② epithelial cell proliferation, hypertrophy, with spine cell layer thickening; ③ granule cell layer thickness, epithelial legs extended, widened; ④ epithelium under a round stromal cells and lymphocyte infiltration. Morphological characteristics of someone under the organization will be divided into two cervical leukoplakia, cervical epithelial surface only 2 to 3 layers keratosis or incomplete keratosis, its spine cells under basal cell layer and to maintain a normal or benign hyperplasia, as leukoplakia Ⅰ level; keratosis under the epithelial cells of atypical hyperplasia, as leukoplakia II level.