How the treatment of systemic lupus erythematosus

On the special organ systems affected: (1) lupus nephritis more than 30 years, hormone has been the treatment of lupus nephritis main ingredients, but could not prevent more than 90% of lupus nephritis patients access to renal failure, long-term efficacy is highly unsatisfactory. 20 since the mid-1980s, experience has shown that high-dose intravenous cyclophosphamide pulse therapy to prevent renal failure and fibrosis. Cyclophosphamide dose of shock therapy: 0.5-1 per square metre surface area grams, monthly or every three months one time, and taking daily prednisone (MP) 10-20 mg to control extra-renal manifestations. Cyclophosphamide given at the beginning of each month an impact on pending proteinuria negative can be changed after the February-March 1. Intravenous cyclophosphamide therapy long-term impact will affect gonadal function, in particular will lead to ovarian failure. In addition, will increase in the potential risk of cancer. Cyclosporine (cyclosporine A) in the treatment of lupus nephritis value, in recent years attracted universal attention. (2) central lupus systemic lupus erythematosus of the central nervous system, in order to diffuse the most serious diseases. If the violation is broad in scope, causing coma, such as high fever. Treatment mainly to save lives. Can be methylprednisolone (methylprednisolone) per kg body weight per day 1-2 mg, at the intravenous injection, such as no improvement within 48 hours, the dosage should be doubled, intravenous drip until symptoms improve awareness restored to normal conditions tend to be stable and progressive reduction medicine. If only mental symptoms can be diazepam (stability) or chlorpromazine, and in the middle of hormones. If epilepsy-like seizures can be stable or increase in the high-dose hormone therapy. :-Some of the sexual performance of dementia patients, application of the hormone in regular spiritual, mental test, and observe the effect of hormones. (3) lupus thrombocytopenic purpura a serious reduction of platelet lupus, can be applied prednisone (MP) per kg body weight per month 1-2 mg diehards also reported Application splenectomy treatment, but far period was dissatisfied with the results. Vincristine can be used intravenous dose per square metre surface area of 2 mg, 1 week, for four weeks. (4) antiphospholipid syndrome and because the syndrome often launched, venous thrombosis, can be used anti-clotting drugs, in general, the use of enteric-coated aspirin 100-300 mg. Had thrombosis of the patients should be long-term use of warfarin, prothrombin time maintained at 25-30 seconds (normal for 12 seconds) in order to prevent recurrence. Of course, the original into the pathogenesis of systemic lupus erythematosus patients, depending on the circumstances, will be based upon the aforementioned programme for treatment.