Moerch - Woltmann's syndrome

Overview known as "zombies" syndrome. Etiopathologic etiology and pathogenesis mechanism is not known. Most researchers believe the disease lesions in the central nervous inhibition among neurons or muscle spindle in the feedback loop r Campaign Neuron. Clinical features of the gradual onset of chronic persistent progress in the whole muscle rigidity, suddenly stimulated irritable, sleep after relax. Men accounted for 70%, for the first multi-trunk muscle pain and seizures electrogoniometer; flu, a few weeks or a few months involving the limbs, progressive development of free movement to influence the sustained muscular rigidity, variable degree. Sleep may disappear, can be impatient tone, mood change, the sudden movement of paroxysmal pain induced convulsion. Sustainable for a few minutes, and with anxiety, palpitations, high blood pressure, etc.. Sensory and intellectual unaffected. Succinic acid with choline, curare, the South American anti-alkali has been conduction other neuromuscular blockers, persistent muscle rigidity reduce or disappear, Procaine peripheral nerve block or tetracaine spinal anesthesia to alleviate muscle stiffness. EMG quiet state Visibility persistent discharge, no individual action potential anomaly, only time. Differential diagnosis (1) ankylosing myopathy (myotonia myopathy) for unknown reasons a group of muscles meat disease, it is generally believed that the incidence of muscle rigidity directly with the muscle cell membrane structure and function abnormalities. Clinical features of the skeleton contraction after contraction and relax; Electrical stimulation, mechanical shock when agents muscle excitability increased; repeated muscle contraction or after repeated electrical stimulation of skeletal muscle relaxation, the symptoms disappeared. cold environment tonic increase, EMG is a continuous high-frequency after discharge. Campaign to cut off the nerve root and curare, such as atropine injection did not affect the incidence of muscle stiffness. (2) Parkinson's syndrome (parkinsonism) of primary or encephalitis, and carbon monoxide poisoning caused by secondary lesions. Clinical characteristics of the tremor, muscle rigidity and movement reduced. Tonic is due to extrapyramidal increased muscular tension, muscle and impetus antagonistic muscle tension has increased, patients to special gesture, we can not do fine motor, panic gait, mask face, diagnosis more difficult. (3) liver degeneration (hepatolenticular degeneration) is an autosomal recessive genetic disorder of copper metabolism in familial disease. Chang violations or abuse of young people, the clinical manifestations of aggravated sexual limb tremor, muscle rigidity, dysarthria, mental changes, Cirrhosis and corneal pigment ring, and other symptoms. Urinary copper content increased, serum total amount of copper and ceruloplasmin reduce serum copper oxidation activity decreased. (4) Lane Gibbs disease (Satoyoshi rat model) for the conduct of pain cramps, Hair loss and amenorrhea, and other endocrine disorders, diarrhea, abnormal glucose metabolism. epiphyseal line sometimes see the destruction of bone and joint diseases and stunting. Lesions progress of the entire gastrointestinal mucosa atrophic changes, sometimes gastrointestinal polyps kind uplift, But early X-ray examination gastrointestinal no significant abnormality. (5) Lssacs-Mertens's syndrome is also called muscle fiber action sweating syndrome, neural muscular rigidity. Children, adults can onset, progressive course, the main manifestations of muscular twitch with myotonic cramps, severe muscle spasm induced pain, Systemic and excessive sweating, muscle over the continued contraction in the distal limb, after the impact of the proximal, trunk and facial muscles. Rest, sleep, or epidural anesthesia, muscle disease -- still plans to show sustained discharge, curare. stupid proper English or sodium amide in treatment can inhibit muscle fiber action and discharge. (6) It should also be noted other except on nuclear lesions caused by hyperreflexia, glycogen disease, tetanus, Hypoparathyroidism appetite, Hysteria disease.