Wednesday, March 12, 2008
Pituitary dwarfism disease
Overview pituitary dwarfism before puberty means anterior pituitary growth hormone deficiency - induced growth retardation. Clinical divided into idiopathic and secondary, for the former, the total pituitary dwarfism 60-70%. the latter because the hypothalamus-pituitary organic diseases caused mainly craniopharyngioma, such as the pineal gland tumor. Foreign dwarfism in the incidence rate of 1/5000, China has yet to see statistics. At present, the disease only effective treatment is human growth hormone (hGH) replacement therapy. A clinical performance. Obstacles to growth : a birth, after 2002 the growth has gradually slowed down, short stature, well proportioned, the adult children may still face, subcutaneous fat, muscle is underdeveloped; Skeletal maturity retardation, skeletal age than younger age, intelligence and considerable age. 2. Sexual Development Obstacles : male penis small, cryptorchidism, no beards, like Tone children. No female menstruation, not breast development, small uterus, genital naive, no hair. A diagnosis. Short stature sound balance of normal intelligence, not sexual development and the lack of pubic hair. 2. X-ray bone naive. 3. Serum levels of growth hormone reduced. 4. Insulin hypoglycemia test, stress test arginine had no reaction. 5. Except for Turner syndrome, dwarfism thyroid cartilage dysplasia, Physique Growth retardation or delayed puberty. A treatment. Growth hormone replacement therapy; 2. Synthetic anabolic steroid therapy; 3. Other endocrine dysfunction hormone replacement therapy; 4. Etiology of a drug treatment. Pituitary dwarfism as a diagnosis, early treatment, Currently the only effective treatment for human GH replacement, and has begun gene recombination technology production hGH. 2. In the absence of growth hormone medical unit available synthetic anabolic steroids or human chorionic gonadotropin used interchangeably. An auxiliary inspection. Pairs short stature various dwarfism, shall be subject to inspection bound by the limitations of the "A" and "B", to determine whether the pituitary dwarfism. 2. Not sure of the diagnosis or conditional, be limited check box "A", "B" and "C", other reasons except to the Dwarf.
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