Retinitis pigmentosa

Overview retinitis pigmentosa ( primary retinal pigmentary degeneration) is a category visual function for the genetic damage retinopathy. A typical fundus changes to the optic nerve head Jihuang, small vessels to small and near the equator of osteoblast-like pigment spot calmly. Night blindness and vision narrow is the main complaint. The disease usually involved eyes, is a relatively common genetic eye disease, a close relative married a descendant of particular styles, Patients and their families should be associated with high myopia, mental disorders, epilepsy, mental decline and the deaf, and other symptoms. Etiopathologic machine now that the disease retinitis pigmentosa pigment epithelium is a highly developed system of phagocytic activity is causing defects photoreceptor cells outside the phagocytosis deficiencies, the impact of outside metabolism, shedding the disc membrane accumulation, may become self-antigen, autoimmune reaction occurred. This pigment epithelial defects related to genetic factors. In addition, endocrine disorders, Trace elements metallurgy and abnormal metabolism, nutrition and obstacles such as retinopathy sclerosis hypothesis. Clinical manifestations of the disease characteristics : There were early night blindness, dark adaptation reduced visual acuity can be maintained for some time, but gradually narrow vision, During the late center visually impaired vision was tubular, patient hard work and life were inconvenienced. Inspection electroretinogram (ERG) abnormalities, usually occur before clinical manifestations. Electro-oculogram (EOG) not normal, or even disappear. Fluorescein angiography as follows : ① pigment epithelium : In early retinal artery or arteries occur in the early stage of the diffuse fluorescence speckle-strong district. ② choroidal : Early angiography can be seen patchy choroidal capillary perfusion without delay or reperfusion. ③ retinal vascular : central retinal artery filling time was significantly delayed, vascular permeability increase, DVD and its environs have strong fluorescence. At present there is no effective treatment therapy. Can be considered : vasodilators, vitamin A, vitamin B1, B6, E treatment.