What is diffuse toxic goiter?

Diffuse toxic goiter, also known as exophthalmos goiter, graves disease or Pakistan-Mrs disease, hyperthyroidism is the most common type, about 90% of patients with hyperthyroidism. Diffuse toxic goiter and the cause of other types of hyperthyroidism is obviously different, it is due to immune dysfunction that is caused by autoimmune. Can cause immune dysfunction in a variety of lymphokines and thyroid autoantibodies, which goiter, thyroid hormone secretion hyperthyroidism, and the resulting series of the signs and symptoms of hyperthyroidism. Immune dysfunction may also cause exophthalmos. The main symptoms of the disease: flustered, Pare, sweating, loss of appetite hyperthyroidism, an increase in bowel movements, suffering from weight loss, agitation, etc.. The vast majority of the patients have goiter, bilateral diffuse swelling, soft texture, smooth surface, without nodules (with a few exceptions). Only a few patients with goiter. Thyroid palpation may have minor tremor, and auscultation vascular murmur. Approximately 40 to 50% of patients with exophthalmos (mostly Bilateral). Serum T3 and T4 levels increased serum thyrotropin lower iodine 131 thyroid uptake rate increased serum thyroid stimulating antibody positive.