Why cirrhotic patients prone to fatigue?

In which the body is unable to fatigue fatigue, decreased physical, mental poor. Since the extent of feeling tired mild to severe fatigue, weakness and the extent of the activities associated with liver disease. A lack of reasons: often in patients with long-term loss of appetite, eating less, resulting in insufficient heat absorption into the body and can not meet their nutritional needs. Abnormal liver function, carbohydrates, protein, fat metabolism, and other obstacles in the middle, a lack of energy. Biliary excretion of liver damage or poor, the blood cholinesterase decreased, affecting nerves, muscles of normal physiological function. Cirrhosis of liver glycogen, lactic acid into obstacles in the process, muscle lactate accumulation after excessive fatigue caused. Cirrhosis, vitamin E absorption barriers caused nutritional muscular atrophy and myasthenia gravis.