Tuesday, March 11, 2008

Pulmonary fungal infections

Pathology and pathogenesis of different fungi and bacteria, which can be as mammalian cells, nuclei, nuclear membrane and the chromosome, Only bacteria and single chromosome, there is no real nuclear and nuclear membrane. Fungi can be sexual or asexual reproduction, with the various spore classification characteristics. Fungi exist in the natural world to a shape, and the infected host, which is abnormal morphology. Actinomycete bacteria referral cards kinyoun like tuberculosis, but no cell structure of antifungal agents is not sensitive, and the right phage and anti-drug sensitive cells, like the cells. Some fungal infection endemic difference. Race and endocrine factors may also be affected to some extent. Human health of the fungi with strong resistance, the following conditions fungi can enter the lungs and cause pulmonary fungal infections. More fungal growth in the soil, air emissions spores can be inhaled into the lungs (exogenous), such as aspergillosis, Slave cards bacteria, cryptococcosis, histoplasma capsulatum. Some of oral fungal parasite, when the body's immune system decline (such as diabetes) can cause lung infections, For example, oral candidiasis, skin, intestinal and vaginal the parasite; actinomycosis of caries hyperparasite. Other parts of the body may also be infected by fungi or lymphatic blood circulation to the lungs, such as the neck, Subphrenic lesions of actinomycosis. These are secondary pulmonary fungal disease. Intravenous nutrition therapy central venous catheterization as long retention time, high glucose concentration is not suitable for bacterial growth, But the growth of Candida albicans can be caused Candida septicemia. In recent years, because of antibiotics, hormones, cytotoxic drugs and immunosuppressant the extensive application pulmonary fungal infections are gradually increasing trend. Pathological changes have allergies, purulent inflammation or chronic granulomatous. X-ray variety, no characteristics, as bronchial pneumonia, lobar pneumonia or chronic small nodules, and even mass shadow. Relying on the diagnosis of fungal culture results morphological identification. Serological tests antigen skin test for reference only. At present there is no ideal drug, amphotericin B for the majority of pulmonary fungal drugs remain effective, but because of its side effects more, its application is restricted. Other drugs are still fluorocytosine, - Mi Kang, ketoconazole, Nysfungin also may choose to use. Clinical findings often secondary fungal pneumonia in a large number of broad-spectrum antibiotics, adrenal cortical hormones, immune inhibitors applications, may also result in vivo induced indwelling catheter. Therefore, the medical staff should be on guard against, it is more important than treatment.

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