Sjogren's syndrome is the cause of what

The primary Sjogren's syndrome of unknown etiology, The following factors may be relevant: (1) genetic factors Some scholars observed that Sjogren's syndrome patients have some family history, including 12% of the relatives of the Sjogren's syndrome are similar lesions. Foreign Sjogren's syndrome was observed that the first-generation relatives in 40% of the lacrimal gland secretion reduced. In recent years, through genetic studies of immune found HLA (human leukocyte antigen) gene and Sjogren's syndrome autoantibody formation and clinical performance. In Sjogren's syndrome patients, human leukocyte antigen (HLA) in the HLA-DR3, HLA-DRw52 and HLA-B8 frequency increased. (2) infection present study, the incidence Sjogren's syndrome and multiple virus infection. Epstein-Barr virus infection is a common human herpes virus. Because of its high degree of activation of B lymphoid proliferation performance, in Sjogren's syndrome by the anti-SSB antibodies SSB antigen recognition in the Epstein-Barr virus containing the gene, in the lacrimal glands, salivary glands, kidneys and lips gland presence of Epstein-Barr virus early antigen and, deoxy ribonucleic acid (DNA). Retroviral infections like Sjogren's syndrome can be the dry mouth, swelling of the parotid gland performance. Probably cross-infection through molecular simulation or super-antigen reaction role in the disease started to become a factor -. (3) sex hormone estrogen to immunization activities too. Women Sjogren's syndrome is almost the incidence of male 10 times, suggesting that the changes in sex hormones in the pathogenesis Sjogren's syndrome have a role. Sjogren's syndrome in the invasion of a variety of factors, caused by abnormal immune response through a variety of cytokines and inflammatory mediators, the Sjogren's syndrome caused tissue injury.