Sjogren's syndrome which clinical manifestations

Onset of primary Sjogren's syndrome and more slowly, Start not obvious or very specific symptoms, patients often several years after treatment. (1) Symptoms salivary glands, lacrimal gland, and other parts such as the respiratory, digestive, skin, vagina and other organs of local body, the damage may result in decreased secretion symptoms. Because of the salivary glands and lacrimal gland size and location also more superficial, so obvious clinical symptoms. ① levy patients have dry mouth saliva reduced dry mouth, part of the population can be a very serious that carry water; regardless, will be required to frequently drinking water. Because saliva reduced, more than half of the patients in a number of difficult to control dental caries - " 'rampant caries": First black teeth gradually, and then small pieces falling out teeth rapid expansion can not be repaired by the end tooth root left off. Parotid or submandibular gland repeated, alternating bilateral swelling, accompanied by pain and tenderness, and sometimes the temperature increased. Most of the patient's pain in 1-2 weeks after its own faded, a small number of patients are left over from the last permanent swelling of glands. After Tongue involvement in the tongue, the lesion, tongue nipple atrophy, Tongues, a smooth-shaped. A tongue pain, sometimes ulcer. ② levy because of dry eyes lacrimal gland secretion decreased from drying of keratoconjunctivitis, a dry eye, foreign body sensation, tear less, or even no tears. Some patients appeared jealous,eye fatigue: and even vision problems. '(2) systemic symptoms about 70% of Sjogren's syndrome patients, in addition to symptoms of a gland, a tolerable level of weakness, joint and muscle pain, fever and other symptoms. ① mucosa myeloid the skin disease progress, impact sweat glands and sebaceous gland secretion, there will be the skin drying Matt. Due to the high hypergammaglobulinemia, there will be Purpura-like rash, a rice grain-sized, clear red border, was particularly prevalent in the lower extremities, appeared in batches, each lasted for 10 days, self dissipated; left a pigmentation. A small number of patients that nodules erythemoid rash. Some patients have oral ulcers and Raynaud's phenomenon, genital ulcers, and so on. ② articular muscle of about 70 percent of patients the pain Festival, arthritis or 10 per cent. Size joints can be involved, symmetric and non-symmetry, for the performance of joint pain, morning stiffness, and intermittent chronic synovitis more arthritis, a rare joint deformity and dysfunction. Often muscle-ache, and less than 10% of patients in polymyositis. ③ kidney According to statistics, half of the patients have kidney damage. Clinical symptoms vary widely and light are asymptomatic, who may re - renal failure and death. ④ nervous system Sjogren's syndrome patients, there will be all kinds of different nerve system damage to the performance of the brain, the cerebellum, spinal cord, brain and peripheral nerve lesions may arise, the central nervous system occurred in 5%, as follows: A. Epilepsy -like attack; B. Mental disturbance of consciousness and symptoms, such as hallucinations, suspicion, persecution paranoia,coma; C. Similar symptoms of multiple sclerosis, a brain, the optic nerve, such as multi-level spinal cord damage; D. Focal symptoms, such as hemiplegia,ataxia, brain lesions. More peripheral nerve involvement, and performance for lower extremity numbness, pain, peripheral sensory abnormalities, and carpal tunnel syndrome, such as low tendon reflex. ⑤ mouth and digestive tract secretion of digestive fluid reduction, Jin appeared fresh and dry dysphagia, abdominal discomfort, abdominal distention, abdominal pain and constipation. Some patients in the liver, elevated liver enzymes and jaundice, and so on. A small number of patients have splenomegaly. The disease can be associated with chronic active hepatitis, cirrhosis, and primary biliary cirrhosis occult. Have subclinical disease of the pancreas showed elevated serum amylase and pancreatic exocrine function lower, but acute and chronic pancreatitis rare. ⑥ a nasal respiratory drying, no nose, throat dry, hoarse voice, dry cough, sputum or phlegm without difficult easily with chronic bronchitis, interstitial pneumonia, diffuse interstitial lung disease or a result of bronchial pneumonia cough , the lack of oxygen, such as breathing difficulties and fever symptoms, and often pleurisy. Most patients only showed abnormal pulmonary function or lung K Line films showed interstitial lung disease without clinical manifestations. ⑦ lymphatic system Sjogren's syndrome is the basic features of the lymphoid tissue hyperplasia and infiltration of the site. Sjogren's syndrome in the lymphoma incidence rate 44 times that of the normal control population. Therefore, Sjogren's syndrome autoimmune be regarded as a common basis and tumor are typical examples. ⑧ blood system and some patients hemoglobin, leukocytes, platelets normal, but very few indicators at the same time reduce the two.