What are the systemic lupus erythematosus and systemic symptoms of joint performance

Systemic lupus erythematosus can be acute, fulminant onset can be chronic and latent onset, accompanied by repeated attacks and mitigation. Clinical manifestations of systemic lupus erythematosus variety, the onset different, multiple organ system may be involved at the same time, but also has a number of organs involved in several systems, so diverse clinical manifestations easily misdiagnosed as type rheumatoid arthritis, glomerulonephritis, pericarditis, aplastic anemia, mental illness and so on. The most common early clinical manifestations, and more non-specific systemic symptoms. 80% -100% of the patients with systemic lupus erythematosus in early weakness, skin lesions can occur in, joint pain and other symptoms before. Fatigue may be a sign of lupus activity. 60% of the patients have decreased body weight, and are often accompanied by other systemic symptoms. Worsening of the illness, or weight can be gradually dropped sharply. More than 80% of the patients had a fever, and most of them high fever. Young patients more vulnerable to heat. Therefore, the unexplained fever with multiple systems and injury of women, we must exclude the possibility of systemic lupus erythematosus. Joint pain and arthritis is the most common systemic lupus erythematosus one of the first symptom. Almost all patients at the beginning of the course of disease or some time have joint pain. Joint swelling in the multi-system damage occurred in the first six months to five years that exist, but often with skin lesions, fever and other visceral injury simultaneously. Often means involving the proximal (toe) between joints, knee, wrist and metacarpophalangeal joints, followed by the ankle, elbow, shoulder, a small portion of patients also involved metatarsophalangeal joints and hip joints, was attack, Symmetry joint pain, swelling and morning stiffness accompanied, joint inspections have been able to detect the swelling, tenderness and pain activities, and similar to rheumatoid arthritis, early in the disease may cause misdiagnosis. Only some arthritis joint pain without objective evidence. Generally do not cause joint deformities, but there are also 4% -8% of patients by joint pain and swelling after repeated; there will be subluxation and contracture, which have joint deformities. Systemic lupus erythematosus and arthritis patients in the X-ray examination, in addition to a soft tissue swelling around joints diffuse osteoporosis signs, the articular cartilage or bone damage relatively rare. There may be a small number of patients with rheumatoid arthritis similar to the erosion of the joint disease. Merger joint effusion, fluid volume is usually less, its appearance Qingliang, protein content and low cell count, the general white blood cell count less than three x109 / l, lymphocyte predominance, the effusion of a lower level of total complement, and Rheumatoid arthritis different. 7% -10% of patients with rheumatoid nodules, rheumatoid arthritis and similar to the distribution, and is common in olecranon extension of the metacarpophalangeal joints. 5% -10% of patients with systemic lupus erythematosus bone necrosis, the disease is an important reason why patients maimed. The site is the most frequently involved the femoral head showed persistent hip pain and movement disorders. Almost all the patients in the event of osteonecrosis of the previous two years, has the history of adrenal cortical hormones, and generally used by the larger dose. Adrenal cortical hormones long-term use of patients, especially the use of larger doses, there may be osteoporosis. In the event of a fracture often before clinical symptoms. About 70% of the patients with systemic lupus erythematosus in muscle-ache, weakness and muscle tenderness, such as myositis clinical manifestations, but only 5% -10% of patients with the inflammatory myopathy. A part of the patients with polymyositis and drug therapy, common glucocorticoid drugs and chloroquine, the former particularly.