What is the nephrotic syndrome

Nephrotic syndrome is proteinuria (24 hour urine protein more than 3.5 grams) and hyperlipidemia characterized by varying degrees of SARS. Common causes can be primary glomerular disease (such as primary glomerular inflammation, focal glomerular sclerosis, etc.), secondary nephritis (such as lupus nephropathy, diabetic nephropathy, etc.) , as well as secondary infection (such as bacteria, viruses, etc.), circulatory system diseases, such as drug poisoning caused. Early this disease basement membrane lesions lighter, As the disease gradually progress from the large number of protein in urine drained a plasma protein is an important reason why lower. Plasma protein level falls, particularly albumin decreased significantly, from plasma colloid osmotic pressure drop of liquid to the bloodstream to the extravascular leakage, resulting in edema and effective blood volume decrease. The nephrotic hyperlipidemia have the mechanism is not yet clear. Large urinary protein loss, due to increased liver albumin synthesis, synthesis lipoprotein also increased as a result of hyperlipidemia. In addition, lipoprotein lipase activity decreased removal of the lipid lowering, may also partly due.