Nephrotic syndrome appeared highly swelling of the reasons for that?

Nephrotic syndrome reason for the high degree of edema: (1) plasma colloid osmotic pressure lowering: Vascular by the exchange of body fluids inside and outside on both sides of osmotic adjustment. Osmolality including colloidal crystals osmotic pressure and osmotic pressure, Crystal material from the former (mainly electrolyte), through its free capillary wall, so the exchange of body fluids inside and outside the vascular little effect on the latter mainly from protein (mainly albumin), not because of its freedom through capillary wall, so it is a vascular fluid exchange of the major internal and external factors. Nephrotic syndrome, as a large number of plasma protein from urine loss caused hypoproteinemia, resulting in lower plasma colloid osmotic pressure When the normal 3.3 to 4 kPa to 0.8 ~ 1.1 kPa, vascular Moisture within the organization to hypertonic solution between mobile and edema occurred. (2) effective blood volume decrease: the relocation of plasma water to effectively reduce blood volume, which resulted in the following changes in the body: through the receptor capacity to antidiuretic hormone (ADH) increased, the increase in renal tubular reabsorption water through excited kidney - - angiotensin - aldosterone system, a secondary Hyperaldosteronism so that the tubular reabsorption of sodium increased natriuretic factor inhibiting the formation to decrease renal sodium row. In the case of water, sodium retention, and further increased edema. Together these two factors caused a high degree of swelling nephrotic syndrome.