How lupus nephritis medication

Traditional treatment of lupus nephritis is the hormone drug, But in recent years, the Clinical Practice shows that the use of poison cell-based treatment, especially the use of cyclophosphamide for intermittent impact than simply using hormone therapy are much better effect. Therefore, the treatment of lupus nephritis mainly cyclophosphamide plus hormones, and not simply by hormones.
(1) hormone: general use prednisone, the first stage before treatment, adult is 1 mg / kg daily morning Dayton served until eight weeks after the reduction, by 5 mg per week, to small dose (next day morning 1 mg / kg) to Dayton yesterday morning service, according to the specific situation persists for a period of time, after better efficacy reductions until maintain volume (yesterday morning 0.4 mg / kg). Some people think that, lupus nephritis patients should be taking hormone life, the general amount of prednisone every other day morning serving 10 to 20 mg. It is worth noting that before the first dose of hormones must be adequate, inadequate dose (<30 mg / d) is often ineffective, glomerular lesions will continue to progress and become irreversible fibrosis caused by renal failure.
Particularly severe or fulminant disease, high fever of 40 ° C, extensive rash and Purpura, proteinuria, large doses can also be used hormone therapy. If the unconditional use of methylprednisolone, use of dexamethasone 150 mg / d replaced, the effect good.
(2) cyclophosphamide: lupus nephritis can inhibit the activity and stability of their disease, reducing hormone dosage, and specific antibody inhibited the effect particularly good, lupus nephritis to eliminate non-specific inflammation and T lymphoid cell-mediated immunity also good effect. Research shows that cyclophosphamide pulse therapy better than continuous treatment efficacy and fewer side effects. Foreign use of cyclophosphamide every 0.75 ~ 1.0 g/m2 body surface area, intravenous drip, every 1 to 3 months shocks 1 At the same time, low dose oral prednisone. Improved domestic cyclophosphamide pulse therapy, please refer to the aforementioned related content.