Thursday, March 20, 2008

Systemic lupus erythematosus kidney damage pathological changes is how typing?

Lupus nephritis histological changes can be divided into activities of the indicators (A1) and chronic indicators (CI). Glomerular disease, Activities indicators include: cell proliferation, cellulose-like necrosis, nuclear fragmentation, cell crescentic, transparent kind thrombosis, platinum ear-like change and leukocyte infiltration, chronic indicators for glomerulosclerosis and fibrous crescentic. Tubulointerstitial lesions, activity index for mononuclear cell infiltration of indicators including chronic interstitial fibrosis and tubular atrophy. According to 1982 WHO classification criteria proposed, lupus nephritis by pathological changes differences divided into six types: Type I: normal glomerular A, light microscopy, electron microscopy and immunofluorescence no abnormal changes; B, normal light microscope, but immunofluorescence and / or electron microscopy see mesangial area immune complex deposition. Type: Mesangial lesions A, mesangial matrix widened with mild or mesangial cell proliferation B, the middle-of mesangial cell proliferation III: focal segmental glomerular nephritis (with light or moderate mesangial lesions) A, including dynamic necrosis lesions B, activities and sclerosis lesions C, sclerosis lesions Type IV: diffuse proliferative glomerulonephritis (mesangial - within the capillary proliferation / endothelial under extensive sediment) A, no obvious nodular lesions B, including mobility necrotic lesions C, activities and sclerosis lesions D, sclerosis lesions V-type: membranous glomerulonephritis A, simple membranous nephropathy B, with type II lesions C, accompanied III lesions. D, with type IV lesions Ⅵ type: sexual sclerosing glomerulonephritis

No comments: